Inherited bleeding disorders

Controversies in Inherited Bleeding Disorders.

Recent years are witnessing key developments in treatment approaches for congenital bleeding disorders (CBD), in particular the hemophilias, but also other factor deficiencies.1,2 Moreover, cooperative multinational efforts are providing advances in our knowledge of pathophysiological, clinical, and management aspects of these disorders, including the more rare abnormalities.3–6 However, despit...

Management of Inherited Bleeding Disorders in Pregnancy

Evaluation the dentists’ awareness of inherited bleeding disorders and anticoagulants in Shiraz

Background Some of the dental procedures can cause bleeding. Bleeding control can be difficult in some patients because of systemic disease or chronic anticoagulant therapy, so they may be at increased risk for bleeding occurrences or even death following invasive dental procedures. This study was schemed to measure the knowledge of general dentists in Shiraz city regarding coagulation tests ...

Introduction to a series of reviews on inherited bleeding disorders.

Hematology can proudly claim to have led many of the recent advances in the application of molecular science to enhancing the diagnostic and treatment potential for disease. Although every issue of Blood contains new insights into the integration of molecular knowledge for improved clinical care, the paradigm of molecular medicine can be traced to the late 1970s/early 1980s, with advances in un...

Platelet von Willebrand factor in inherited and acquired bleeding disorders.

The majority of plasma proteins involved in the mechanisms of hemostasis are loosely adsorbed on the platelet surface. A few of them, however, can also be measured in washed platelets, in which they are contained in the intracellular organelles called a granules. The main proteins involved in blood coagulation concentrated in platelets are von Willebrand factor (vWF), fibrinogen, and factor V. ...